Though the Japanese had had some interactions and dealings with the Ainu (or Emishi) of Hokkaidô in earlier periods<ref>Including as early as the late 15th century, when the [[Ando clan|Andô clan]] and [[Takeda Nobuhiro]], ancestor of the Matsumae clan, were active in Ezo.</ref>, it was in the Edo period that directed policy was first aimed at the island of Hokkaidô, then called Ezo. | Though the Japanese had had some interactions and dealings with the Ainu (or Emishi) of Hokkaidô in earlier periods<ref>Including as early as the late 15th century, when the [[Ando clan|Andô clan]] and [[Takeda Nobuhiro]], ancestor of the Matsumae clan, were active in Ezo.</ref>, it was in the Edo period that directed policy was first aimed at the island of Hokkaidô, then called Ezo. |