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Born in [[Nagato province]], he entered [[Nanzen-ji]] in [[Kyoto]] as an initiate or novice at the age of nine, and became a Buddhist priest at age 16, studying under the priest Keiho Genkin<!--景蒲玄忻-->. While there he also studied Confucianism under Ishô Myôtei<!--惟正明貞--> of [[Kennin-ji]], and Keishô Zuidô<!--景召瑞棠--> of [[Tofuku-ji|Tôfuku-ji]], both of whom had studied in turn under Giyô Hôshû<!--岐陽方秀, 1361-1424-->.

Born in [[Nagato province]], he entered [[Nanzen-ji]] in [[Kyoto]] as an initiate or novice at the age of nine, and became a Buddhist priest at age 16, studying under the priest Keiho Genkin<!--景蒲玄忻-->. While there he also studied Confucianism under Ishô Myôtei<!--惟正明貞--> of [[Kennin-ji]], and Keishô Zuidô<!--景召瑞棠--> of [[Tofuku-ji|Tôfuku-ji]], both of whom had studied in turn under Giyô Hôshû<!--岐陽方秀, 1361-1424-->.

Keian joined a mission to [[Ming Dynasty]] China led by Ten'yo Seikei<!--天與清啓-->, which left Kyushu in [[1468]] and arrived in [[Ningbo]] a year later. Keian and the members of the mission received an audience with the [[Xianzong Emperor]], after which Keian traveled to [[Suzhou]] and [[Hangzhou]], and was able to study with a number of scholars of Neo-Confucianism. He spent six years in China, studying with these scholars and reading texts such as the ''Sishu jishi''<!--四書輯釋--> by Ni Shiyi<!--倪士毅--> from the [[Yuan Dynasty]], and the ''Sishu xiangshuo''<!--四書詳說--> by Cao Duan<!--曹端--> of the Ming.

Keian joined a mission to [[Ming Dynasty]] China led by Ten'yo Seikei<!--天與清啓-->, which left Kyushu in [[1468]] and arrived in [[Ningbo]] a year later. Keian and the members of the mission received an audience with the [[Chenghua Emperor]], after which Keian traveled to [[Suzhou]] and [[Hangzhou]], and was able to study with a number of scholars of Neo-Confucianism. He spent six years in China, studying with these scholars and reading texts such as the ''Sishu jishi''<!--四書輯釋--> by Ni Shiyi<!--倪士毅--> from the [[Yuan Dynasty]], and the ''Sishu xiangshuo''<!--四書詳說--> by Cao Duan<!--曹端--> of the Ming.

He returned to Japan in [[1473]], and was forced by the chaos and violence of the [[Onin War|Ônin War]] to move from place to place. After about five years of traveling around [[Iwami province|Iwami]], [[Bungo province|Bungo]], [[Chikugo province|Chikugo]], [[Suo province|Suô]], Nagato, and [[Higo province]]s, he was invited to Satsuma by [[Shimazu Tadamasa (1463-1508)|Shimazu Tadamasa]] in [[1478]]. There, Genju first joined the Ryûun-ji temple. The following year, Tadamasa had a temple built for him, called Keiju-in<!--桂樹院--> or Tôin-ji<!--島陰寺-->, and he began teaching there. He was a strong advocate of Zhu Xi's interpretations, considering anything counter to Zhu Xi's theory to be "not academic."<ref>Takatsu, 256.</ref> He is known to have lectured to Tadamasa himself not only on the teachings of Zhu Xi, but also of the Cheng brothers ([[Cheng Hao]] and [[Cheng Yi]]), who were significant influences for Zhu Xi, and on a text called ''Shujing jizhuan'', by the [[Southern Song Dynasty]] scholar Cai Chen <!--蔡沈, 1167-1230-->.

He returned to Japan in [[1473]], and was forced by the chaos and violence of the [[Onin War|Ônin War]] to move from place to place. After about five years of traveling around [[Iwami province|Iwami]], [[Bungo province|Bungo]], [[Chikugo province|Chikugo]], [[Suo province|Suô]], Nagato, and [[Higo province]]s, he was invited to Satsuma by [[Shimazu Tadamasa (1463-1508)|Shimazu Tadamasa]] in [[1478]]. There, Genju first joined the Ryûun-ji temple. The following year, Tadamasa had a temple built for him, called Keiju-in<!--桂樹院--> or Tôin-ji<!--島陰寺-->, and he began teaching there. He was a strong advocate of Zhu Xi's interpretations, considering anything counter to Zhu Xi's theory to be "not academic."<ref>Takatsu, 256.</ref> He is known to have lectured to Tadamasa himself not only on the teachings of Zhu Xi, but also of the Cheng brothers ([[Cheng Hao]] and [[Cheng Yi]]), who were significant influences for Zhu Xi, and on a text called ''Shujing jizhuan'', by the [[Southern Song Dynasty]] scholar Cai Chen <!--蔡沈, 1167-1230-->.