Yukinaga was the eldest son of Asano Nagamasa and inherited his domain in Kai. He first saw military service in the Odawara Campaign and later fought at the Seige of Ulsan alongside Kato Kiyomasa and his father. Thanks to the help of Maeda Toshiie, he narrowly avoided being implicated in the Toyotomi Hidetsugu scandal of 1595. He and his father supported Tokugawa Ieyasu in 1600 and he personally commanded 6,500 men at Sekigahara (1600). Soon after the Tokugawa victory he was given Wakayama in Wakasa province. He died childless and was succeeded by his younger brother Nagaakira. His sudden death was thought sufficiently odd to prompt suspicions that Ieyasu had had a hand in it.